Codonopsis lanceolata on rat skeletal muscle contractile force and the forced swimming time of mice.docVIP

 PAGE \* MERGEFORMAT 5 Codonopsis lanceolata on rat skeletal muscle contractile force and the forced swimming time of mice Author: Lee Mi-ja, Zhang Hongjia, Liang Ren Zhe, BING Yanhua, He Yonggui, Cui Xun, Jin Zhe [Keywords:] Muscle, Skeletal; contraction; fatigue; Codonopsis; rat; mice Codonopsis lanceolata is rich in vitamins, amino acids and iron, zinc, titanium and other elements, with lowering blood pressure, anti-oxidation, anti-mutagenic, anti-tumor immunity and enhance the role of the body [1 ~ 3]. According to reports, round leaves the party ginseng extract on carbon tetrachloride induced liver toxicity has obvious antagonism [4]. some studies have shown that Codonopsis lanceolata has anti-oxidation, can significantly increase the serum superoxide dismutase (SOD ) activity, reduce lipid peroxidation product malondialdehyde (MDA) content, enhance the body’s ability to eliminate free radicals, reducing the body of free radicals, thereby inhibiting the body aging. This study observed the ethanol extract of Codonopsis lanceolata on the Rat skeletal muscle contractile force and the forced swimming time of mice. 1 Materials and methods 1.1 Material of laboratory animals to take weight 180 ~ 200g of the Department of male Wistar rats and body weight of 18 ~ 20g of male Kunming mice by the Department of Yanbian University Medical Experimental Animal Section. The main instrument used in experiments with RM-6240 multi-channel physiological Signal acquisition and processing system and JZJ101 pressure transducer (50g), from Chengdu Thai Union Technology Co., Ltd. production. Codonopsis lanceolata 500mL / L ethanol extract from Yanbian University, School of Basic Medical Health and Toxicology provided, each mL containing 1g crude drug , clinical preparation of normal saline before use by adding 10g / L diluent. 1.2 Methods 1.2.1 Codonopsis lanceolata on rat skeletal muscle contractile force of the impact will be 28 rats were randomly divided into Codonopsis