Congenital cytomegalovirus infection on birth defects and health damage caused by.docVIP

 PAGE \* MERGEFORMAT 24 Congenital cytomegalovirus infection on birth defects and health damage caused by [Keywords:] congenital cytomegalovirus infection in health damage birth defects HCMV (human cytomegalovirus, HCMV) is a herpes virus, is the most common congenital infection. HCMV generally susceptible in the population, mostly those with normal immunity, latent infection, can carry the virus for life; when the pregnancy or immune function, the latent virus is activated causes recurrent infections. who is the only source of infection, HCMV, HCMV infection in humans, nearly all body fluids (saliva, tears, latex, blood, urine, semen and cervical secretions) contain HCMV.HCMV is now confirmed human teratogens [1], except after infection in pregnant women can lead to miscarriage, premature birth, stillbirth, stillbirth, intrauterine growth retardation, it can also cause birth defects. Congenital HCMV infection and asymptomatic infection into symptomatic infection, the total infection rate was 0.64% (95% CI: 0.60 ~ 0.69%) [2]. Mother after primary infection, the probability of future infection in 40% (24% ~ 75%) [3]. Of these, 10% to 12% of the children born with symptoms in the giant cell inclusion body disease [4], the specific symptoms include: hyperbilirubinemia, hepatitis, hepatosplenomegaly , bleeding, brain malformation (periventricular calcification is common), chorioretinitis. symptomatic patients, 40% ~ 58% of long-term sequelae, the most common sensorineural hearing loss, accounting for 10% 15%. babies born without symptoms, about 13.5% have sequelae, mainly sensorineural hearing loss and neurological damage and cognitive symptoms. mother recurrence of infection, the future 1% probability of infection, the majority of infected children no symptoms, less than 10% of the patients had long-term sequelae, primarily deafness and microcephaly. First, stillbirth, fetal malformation and spontaneous abortion Researchers are using enzyme-linked i