COPD diammonium glycyrrhizinate on NF-B in lung tissue of.docVIP

 PAGE \* MERGEFORMAT 12 COPD diammonium glycyrrhizinate on NF-B in lung tissue of Of: Buli Mei Fen Liu Hongyuan Gongji Han Shi Zhuohua tree into song [Abstract] diammonium glycyrrhizinate Objective (DGPS) for the treatment of COPD rats its mechanism. Methods to experimental passive smoking and intratracheal instillation of rats with LPS combination of methods, induced rat model of COPD . The experimental animals were randomly divided into 3 groups: control group, model group, DGPS treatment group. radioimmunoassay of serum hyaluronic acid (Hyaluronan, HA), and laminin (Laminnin, LN ); liquid phase competition assay of tumor necrosis factor - @ (TNF-@) level; immunohistochemical staining positive cells NF-B, Western blot determination of expression of NF-Bp50; the general structure of lung tissue changes and change under the light microscope. Results DGPS decreased serum HA, LN, TNF-@ levels, compared with the model group were significant (P lt;0.05); DGPS lung tissue NF-Bp50 reduce the number of positive cells and NF- Bp50 protein was decreased. Conclusion DGPS can inhibit the production of cytokines, thereby protecting the remaining lung cells play a role in anti-COPD; and through the lower NF-Bp50 protein expression, reducing the release of inflammatory mediators play a role in inflammation and reduce lung injury. [Keywords:] Chronic obstructive pulmonary disease; glycyrrhizic acid diammonium; hyaluronic acid; tumor necrosis factor - @; NF-B Present study suggests that chronic obstructive pulmonary disease (COPD) in the pathogenesis and pulmonary protease and antiprotease imbalance, oxidative and antioxidant imbalance, substantial and chronic inflammation of lung blood vessels (1). For these reasons led to the airway chronic injury and repair process is not complete, resulting in changes in airway structure and function, namely, airway remodeling, which is irreversible airflow limitation in COPD main (2). and further to develop into a chronic pulm