CSF in immune regulation and its application in allogeneic hematopoietic stem cell transplantation.docVIP

 PAGE \* MERGEFORMAT 22 CSF in immune regulation and its application in allogeneic hematopoietic stem cell transplantation Authors: Chang-British, Xiang-Yu Zhao, Xiao-Jun Huang \ [Abstract] granulocyte colony-stimulating factor (granuloctye colony  stimulating factor, G  CSF) in the mobilization of hematopoietic stem cells during the course of a variety of immune cell function in vivo has an important regulatory role, in-depth understanding of G  CSF immune regulatory role for the to reduce acute graft-versus-host disease (Graft  versus  host diseases, GVHD) occurring, to maintain and enhance graft-versus-leukemia (Graft  versus  leukemia, GVL) effect and reduce the hematopoietic stem cell transplantation in patients with relapse rates of great significance . In this paper, G  CSF on peripheral blood and bone marrow graft immune regulation, G  CSF in immune regulation and Allo  HSCT and cytokines in immune regulation studies are reviewed. [Keywords:] granulocyte colony-stimulating factor Effect of Granulocyte Colony  Stimulating Factor on Immunological Regulation and Its Application in Allogeniec Hematopoietic Stem Cell Transplantation - Review Abstract The granulocyte colony  stimulating factor (G  CSF) plays an important role in regulating fumction of immunocytes in process of mobilizating hematopoietic stem cells. The deep understanding of the immunoregulatory effects of G  CSF has important significance to improve the outcomes of patients with hematological malignancies after allogeneic hematopoietic stem cell transplantation, included alleviating acute graft  versus  host disease, maintaining or enhancing graft  versus  leukmia effects and decreasing the relapse rates. In this article, the immunoregulatory effect of G  CSF on graft of peripheral blood and bone marrow, the immunoregulation of G  CSF and allo  hematopoietic stem cell transplantation, as well as the prospective trend of research on immunoregu