Danhong injection on myocardial ischemia Injury.docVIP

 PAGE \* MERGEFORMAT 11 Danhong injection on myocardial ischemia Injury [ABSTRACT] Objective Danhong injection on myocardial ischemic injury. Methods of coronary artery ligation rat model of myocardial ischemia, the animals were randomly divided into sham operation group, model group, Danshen injection positive the control group (10 g / kg), each dose group Danhong injection (10,20,30 g / kg). Except the sham operation group and model group were given the same volume of saline, the animals in each group after 12,23 h were administered intravenously 1. After 24 h, myocardial infarction measured levels of serum creatine kinase (CK), lactate dehydrogenase (LDH), aspartate amino transferase (AST), Superoxide dismutase (SOD), content of malondialdehyde (MDA) levels and cardiac MDA, SOD content, and record the electrocardiogram ST. Results Danhong injection (20,30 g / kg) dose could significantly reduce myocardial ischemic injury myocardial infarct size, respectively (23.26 + -5.95)%, (20.54 + -9.78)%, while the model group was (36.79 + -8.01)%; the model group was significantly ECG ST segment elevation (0.48 + -0.05 ) mV, and Danhong injection could significantly decrease the dose of ST-segment elevation (0.29 + -0.04), (0.22 + -0.04), (0.17 + -0.03) mV (all P lt;0.01). In addition, the Danhong injection can reduce serum CK, LDH, AST activity and MDA content in serum and cardiac tissue, increased SOD activity in serum and cardiac tissue. Conclusion Danhong injection on myocardial ischemia has a protective effect, which may be related antioxidant related. [Keywords:] Danhong injection; myocardial ischemia; antioxidant Has been demonstrated Danhong injection on renal ischemia-reperfusion injury protection (1,2), but the injection of Danhong no myocardial injury in detail. The experimental point of view from the antioxidant explore Danhong injection on cardiac hypertrophy induced oxidative damage in rats. 1 Materials and methods 1.1 Materials 1.1.1 An