Cystatin C gene G82C with coronary heart disease.docVIP

 PAGE \* MERGEFORMAT 9 Cystatin C gene G82C with coronary heart disease Study: Beijing Guo Xiang-Hong Li Yonghong Home Army [Abstract] Objective To study cystatin C (cystatin C, Cys C) gene 5 ‘end of 82G / C mutation and coronary heart disease in the Han nationality of Gansu in China (CHD, 2 diabetes mellitus (T2DM combined CHD (T2DM + CHD association exists. method using PCR restriction fragment length polymorphism (RFLP analysis of 120 cases of unrelated Han Chinese Gansu (normal control group of 40 patients, CHD group of 40 patients, T2DM + CHD group of 40 patients) in the gene for Cys C variations were detected. Results CHD group, GC, CC and GG genotype frequencies were 38.24%, 2.94% and 58.82%, T2DM in the GC, CC and GG genotype frequencies were 44.12%, 2.94% and 52.94%; normal by the group GC, CC and GG genotype frequencies were 30.0%, 5.0% and 65.0%, G allele frequency in CHD group, T2DM + CHD group and control group were 77.94%, respectively, 75.0% and 80.0 %. genotypes and allele frequencies not significantly different between groups. Conclusion Han population in China, there Gansu Cys C gene 5 ‘end of 82G / C variant of the polymorphism, Cys C gene peptide sites may not China Gansu Han CHD and T2DM genetic factors. [Keywords:] Cystatin C; allele frequency; coronary heart disease Genetic factors in coronary heart disease occurrence and development plays a very important role. Recent research suggests that cystatin C (cystatin C, Cys C protease interaction and organization involved in atherosclerosis (AS) disease pathological process. Cys C gene mutation and its frequency distribution by race, geography and other factors, larger, and its polymorphism and coronary heart disease (CHD relationship is not consistent with results at home and abroad. In this study, case-control study, by 80 cases of CHD patients and 40 healthy human Cys C, high-sensitivity C-reactive protein (hsCRP, interleukin 6 (IL 6, blood lipid and blood glucose levels were de