db - db mice pancreas of matrix metalloproteinase -2 -9 and its inhibitor -1 expression and significance.docVIP

 PAGE \* MERGEFORMAT 11 db / db mice pancreas of matrix metalloproteinase -2 -9 and its inhibitor -1 expression and significance [Abstract] Objective To observe the matrix metalloproteinase (MMP) in the MMP-2, MMP-9 and their inhibitors (TIMP-1) in the db / db spontaneous type 2 diabetes (T2DM) expression in mouse pancreas and its significance . Methods observed by immunohistochemistry db / db mice pancreas, MMP-2, MMP-9, TIMP-1 expression in mouse pancreas. Results MMP-2, MMP-9 positive islet cell products are mainly located in cytoplasm, with the month’s increase in diabetes and increased the expression of the normal group. diabetes between groups, there was significant difference (P lt;0.05). between the normal group, no significant difference (Pgt; 0.05). the same month diabetic group was significantly higher than the normal group, there was significant difference (P lt;0.05). TIMP-1-positive reaction product in the cytoplasm of islet cells in diabetic group and normal group increased with months of age, expression decreased, diabetes There were no significant differences (Pgt; 0.05). the normal between the two groups, no significant difference (Pgt; 0.05). the same month diabetic group and normal group compared with the diabetic group was significantly lower than the normal group, there was significant differences (P lt;0.05). Conclusion Type 2 diabetes may be related to MMPs/TIMP-1s control system is closely related to an imbalance. [Keywords:] diabetes mellitus; pancreas; MMP-2; MMP-9; TIMP-1 Type 2 diabetes (T2DM) accounts for about 90% of diabetic patients, its etiology and pathogenesis are not fully understood. Extracellular matrix (ECM) is a pancreatic islet cell microenvironment are important components, and the viability and function of islet cells closely (1). ECM remodeling, synthesis and degradation balance, eventually leading to disease progression EM accumulate many common pathway to end-stage (2). matrix metalloproteinase (MMP) and t