Deficiency in rat pituitary - adrenal axis and pituitary - gonadal axis correlation.docVIP

 PAGE \* MERGEFORMAT 10 Deficiency in rat pituitary - adrenal axis and pituitary - gonadal axis correlation Author: Min Jian-Xin Wang Jianhong Wu Qinghua Ma Na Min-Chang Liu Haiyun [Abstract] Objective To investigate the deficiency in rat pituitary - adrenal axis and pituitary - gonadal axis function of the relationship between. Method of intramuscular injection of hydrocortisone replication deficiency rat model, using observed in batches slaughtered early, middle and late deficiency in rat pituitary - adrenal axis and pituitary - gonadal axis function indicators, the associated test data analysis to explore the pituitary - adrenal axis and pituitary - gonadal axis variation between and characteristics. Results normal pituitary - gonadal axis hormones in early T and FSH are associated and a negative correlation with advanced CORT and ACTH were positively correlated, the model group of early ACTH and LH significantly negatively related to the mid-FSH and LH model group significantly positive correlation Xing, CORT and T a positive correlation. Conclusions deficiency early stage of pituitary - adrenal axis and pituitary gland - the pituitary gonadal axis hormones have a negative correlation, that is, the existence of mutual inhibition of two-axis; but the medium-term target gland hormones, when there is positive correlation, showing the parallel relationship between two axis while impaired; confirmed that deficiency is a comprehensive dynamic and can be translated into functional state. [Keywords:] the relevance of deficiency of pituitary - adrenal axis pituitary - gonadal axis Kidney-Yang Deficiency involved in nervous, endocrine, immune system changes in multiple system and organ function is the integrated performance. Deficiency permits to carry out more basic research, and many studies have shown that deficiency permits the existence of the hypothalamus - pituitary - target gland axis in different sectors, different degrees of dysfunction, causing the adr