Detection of cystatin C and application of.docVIP

 PAGE \* MERGEFORMAT 13 Detection of cystatin C and application of [Abstract] Cystatin C (Cystatin C) is a low molecular weight non-glycosylated basic protein, since the 20th century, since the mid-80s, by a large number of studies have shown that it has a few factors, high specificity, good accuracy, more timely reflect changes in glomerular filtration rate of an ideal endogenous marker, which exists in various body fluids, there are several ways of its detection in renal function, cancer, cirrhosis, rheumatoid, renal transplantation and broader field of pediatric clinical value, are reviewed. [Keywords:] Cystatin C (Cystatin C GFR 1 Overview Serum cystatin C is the first time Anastasi, etc. in the purified egg cysteine #8203;#8203;protease inhibitor with high purity (cysteine #8203;#8203;proteinase inhibitor, CPI), was renamed the cystatin C. It consists of 122 amino acids with positive charge, such as locus of 9.3, is an alkaline non-glycosylated low molecular weight protein, relative molecular mass of 13300. cystatin C is a cysteine #8203;#8203;protease inhibitor, a member of the family, encoding serum cystatin endostatin C gene in the short arm of chromosome 20, about 615kb, housekeeping genes are, in all nucleated cells at a constant rate of transcription. cystatin C is a secreted protein, in a wide variety body fluids, such as cerebrospinal fluid, saliva, urine, semen, including semen and the highest concentration in the cerebrospinal fluid, urine lowest [1], cystatin C can freely through the glomerulus, and after the degradation of the renal tubular reabsorption , almost no effect under physiological conditions cystatin C stability factor. cystatin has a constant production rate, only by glomerular filtration excretion in the renal tubules is reabsorbed completely degraded [2], this feature makes Serum cystatin C as compelling renal glomerular filtration rate (glomerular filtration rate. GFR) of alternative markers. 2 test set 2.1 Comp