Diabetic lower limb ischemia impaired collateral angiogenesis Advances mechanisms.docVIP

 PAGE \* MERGEFORMAT 16 Diabetic lower limb ischemia impaired collateral angiogenesis Advances mechanisms Study: Sen Zhou Xiangyu Shi Tang Hin He Yanzheng [Keywords:] diabetes mellitus; collateral vessels; angiogenesis Diabetes (Diabetes mellitus, DM) is independent of other risk factors of atherosclerosis and heart disease, peripheral arterial disease caused by the main, the result of the lower extremity vascular disease is a serious complication of diabetes, the incidence rate is normal 4 times. diabetic macroangiopathy Erzhi not only severe ischemic disease, but also accompanied by the formation of collateral vessels of serious damage. In general, patients with peripheral vascular disease, the formation of the collateral arteries enough to compensate the loss by blocking the blood flow However, in diabetic patients, because of their impaired ability to leaving collateral myocardial angiogenesis, extremities, such as severe retinal ischemia. Thus, patients with lower extremity arterial occlusive disease in patients with non-diabetic patients with diabetes five times the rate of amputation [ 1]. angiogenesis in diabetic patients on the causes defect inconclusive. Limb ischemia, hypoxia and inflammation is caused by a major stimulant of angiogenesis. Angiogenesis is divided into angiogenesis, angiogenesis, arterial formation. Yolk sac location with a small group of stem cells, proliferation and differentiation and development through the formation of the most primitive vascular structures This process is called angiogenesis. on the basis of the vascular bed, vascular endothelial cells formed by budding new capillary network, this is angiogenesis [2]. ischemic tissue surrounding the small blood vessels in ischemic tissue irritation and The role of small factors, the formation of adequate lumen diameter of blood vessels, a process known as arterial formation. The main process of angiogenesis is endothelial cells and dissolve the connection between the