Diabetic skeletal muscle VEGF bFGF NGF expression and significance.docVIP

 PAGE \* MERGEFORMAT 11 Diabetic skeletal muscle VEGF bFGF NGF expression and significance Of: Cheng Xiu-Mei Wang Xiaosong Rongshi Ling Zhang Yongjian [Abstract] Objective To investigate the skeletal muscle vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), nerve growth factor (NGF) the relationship between myopathy and diabetes. Methods SD rats were randomly divided into control group and the untreated group. to streptozotocin 50 mg / kg intraperitoneal injection of manufacture observed after diabetic .8 w pathological changes in skeletal muscle, and detected by immunohistochemistry in skeletal muscle VEGF, bFGF, NGF protein expression . Results of model group showed the universality of skeletal muscle atrophy, muscle fiber degeneration and necrosis, VEGF, bFGF, NGF in the model rats significantly decreased the expression of skeletal muscle. Conclusion VEGF, bFGF, NGF expression in abnormal muscle in the diabetic the development of the disease. [Keywords:] diabetes mellitus, skeletal muscle, vascular endothelial growth factor, basic fibroblast growth factor, nerve growth factor Skeletal muscle under insulin-stimulated glucose uptake in the primary site. Research shows that the body use glucose in skeletal muscle is the most important organization, is one of the main targets of high blood sugar damages. Gravis, muscle pain, muscle atrophy is a common diabetes symptoms, diabetes, muscle damage and increased peripheral insulin resistance (1). Therefore, the study of skeletal muscle in the diabetic state for the prevention and treatment of various pathological changes of diabetes and its complications is of great significance. In recent years, vascular endothelial growth factor (VEGF , basic fibroblast growth factor (bFGF and nerve growth factor (NGF in skeletal muscle growth, angiogenesis and muscle repair after muscle injury in the role of more and more attention. This study was designed to investigate VEGF, bFGF , NGF