Development of chloral hydrate suppository.docVIP

 PAGE \* MERGEFORMAT 12 Development of chloral hydrate suppository 【Abstract】 Objective To prepare chloral hydrate suppository, and to explore its quality control methods. Methods oily matrix (semi-synthetic fatty acid glyceride), made of W / O type suppository; use of acid-base titration, determination of chloral hydrate content. Results Preparation of chloral hydrate suppository hardness moderate, stable, able for clinical ease of use. Conclusion chloral hydrate suppository preparation method is simple, accurate and reliable quality control method. Keywords: chloral hydrate; suppository; preparation; Quality Control Chloral hydrate (chloral hydrate) Chloral derivatives are drugs, also known as chloral hydrate, hydrated chloral. It as the earliest and is still used in clinical applications of hypnotic, which is characterized by strong hypnotic effect. Gastrointestinal absorption rapidly, a very short half-life. Chloral hydrate as a safe and effective Zhijing, sedation, hypnotics, clinical common oral and enema, oral solution with penetrating odor and corrosive bitterness, irritation of the stomach large and difficult to accept patients, especially children. Enema inconvenient to use. So, if chloral hydrate suppositories are made through the rectum and other means of absorption, can well solve the above problems. An instrument and reagent Suppository mold (Shandong Qingzhou City Jingcheng Machinery Co., Ltd.); electric constant temperature water bath pan (Model: HSG-IB-2, Shanghai Instrument Group supply and marketing companies). Chloral hydrate (purity of 99.8%, Qingdao Yulong seaweed Co., Ltd.); semi-synthetic fatty acid ester (Chengdu Lutianhua Corson limited liability company); Span-20 (Tianjin Chemical Reagent Factory Fu morning). 2 Preparation of chloral hydrate suppository Weigh the amount prescribed by semi-synthetic fatty acids, glyceride, and placing an evaporating dish on a water ba