Detection of animal models of cerebral ischemia Progress Indicators.docVIP

 PAGE \* MERGEFORMAT 11 Detection of animal models of cerebral ischemia Progress Indicators Authors: Zhou Xia Wan Jun Huang Guojun Dong Country [Abstract] an overview of commonly used animal model of cerebral ischemia in the detection of indicators Research for the study of cerebral ischemia animal model to evaluate the mechanism and provide a basis for experimental studies at the same time easy to choose to use. [Keywords:] cerebral ischemia animal model checking indicators Ischemic cerebral circulation is characterized by reduced blood flow, central nervous system diseases with high incidence, high morbidity and mortality characteristics, seriously affect the quality of life of mankind. Accurate detection of cerebral ischemia in selected indicators of cerebral ischemia animal model of the mechanism study and one of the key links. In this paper, commonly used animal model of cerebral ischemia in the detection of indicators to make a conclusion. A platelet aggregation Blood platelets and high cohesion are the main pathogenic mechanism of cerebral ischemia is one. On the use of arachidonic acid-induced acute cerebral ischemia model in rats showed that [1], the model group to join inducer ADP (final concentration of 2 μ mol / L), respectively, 1,2,4 h were measured after 5 min the largest gathering rate (PAgTmax%), and 1min maximal aggregation rate (PAgVmax%) than those in the control group. Part 2 the percentage of cerebral infarction Production suture method in rats with focal cerebral ischemia-reperfusion model to simulate the human state of ischemic cerebrovascular disease, through the TTC (TTC) staining method to calculate the ischemic area. The results in rats occur within 24h after modeling varying degrees of nerve injury symptoms, compared with control group, ischemic part of the total brain tissue area of a very significant difference in the percentage of [2,3]. 3 brain water content Cerebral blood vessel blockage, the central area of ischemic