Different ratio of ceftazidime - tazobactam in vitro antibacterial activity.docVIP

 PAGE \* MERGEFORMAT 14 Different ratio of ceftazidime / tazobactam in vitro antibacterial activity Author: Zhao Xue-Fu Yu Lou Dragons were the new Yue-Ming Wang Hui Zhang Chen Hui-chen 【Abstract】 Objective To evaluate the different ratio of ceftazidime / tazobactam (CAZ / TAZ) in vitro antibacterial activity. Methods A two-fold agar dilution method different ratio of CAZ / TAZ pairs of 812 clinical isolates of the MIC. The results of different ratio of CAZ / TAZ (1:1,2:1,4:1,8:1) of the 812 clinical isolates have a broad-spectrum antibacterial activity, CAZ / TAZ 1:1,2:1,4: The antibacterial activity of a similar, slightly stronger in the CAZ / TAZ 8:1. Different ratio of CAZ / TAZ on the production of β-lactamase of Staphylococcus aureus, table Portuguese bacteria, Escherichia coli, Klebsiella pneumoniae, calcium acetate Acinetobacter, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, as well as producing ESBLs Escherichia coli, Klebsiella pneumoniae, Acinetobacter calcium acetate antibacterial activity of CAZ stronger than the 2 to 8 times, but the enzyme of Pseudomonas aeruginosa on the production of antibacterial similar activity and CAZ. CAZ / TAZ pairs did not produce β-lactamase of Staphylococcus aureus, table Portuguese bacteria, Pseudomonas aeruginosa, suppurative streptococcus, Streptococcus pneumoniae CAZ similar antibacterial activity. CAZ / TAZ pairs of MRSA, MRSE, Enterococcus faecalis poor antibacterial activity. Conclusions different ratio of CAZ / TAZ have a strong in vitro antibacterial activity, CAZ / TAZ 1:1, 2:1,4:1 antibacterial activity similar, slightly better than CAZ / TAZ 8:1, TAZ enhanced CAZ resistance producing β-lactamase-producing bacteria activity. Keywords: Ceftazidime / tazobactam minimum inhibitory concentration of ceftazidime-tazobactam In vitro antibacterial activities of ceftazidime / tazobactam 【Abstract】 Objective To evaluate the in vitro antibacterial activities