Different solvent extracts of calla lilies in vitro anti-tumor activity of.docVIP

 PAGE \* MERGEFORMAT 10 Different solvent extracts of calla lilies in vitro anti-tumor activity of [Abstract] Objective To study the calla lilies of different solvent extracts of anti-tumor effect. Method of anti-tumor activity in vitro study used MTT assay, target cells, using human lung cancer cell line A549, melanoma cell line B16, human gastric adenocarcinoma cell line BGC-823, neural tumor cell lines NG108-15. Results Alocasia ethyl acetate extract of A549, B16, BGC-823 of the IC50 were 94.6, 541.9,629.5 μ g * ml-1, acetone extract of A549, B16 of the IC50 were 40.9,438.0 μ g * ml-1 , while the calla lilies of cyclohexane, petroleum ether, ethanol and water extracts of various cell lines was relatively large doses of IC50. Alocasia acetone and ethyl acetate extract at 60 g * kg-1, and 36.5 g * kg-1 of the administered dose did not show significant acute toxicity. Conclusion ethyl acetate and acetone extracts had better cytotoxic activity, no apparent acute toxicity, these two parts have good prospects for anti-tumor. [Keywords:] Alocasia anti-tumor activity of extracts of Abstract: ObjectiveTo study the anticancer effects of different solvent extracts from Alocasia macrorrhiza in vitro.MethodsMTT method was used to detect the survival of tumor cells treated with diffenent solvent extract from Alocasia macrorrhiza in vitro, tumor cell A549, B16, BGC-823, NG108 -15 was used as target cell. ResultsThe IC50 of the ethyl acetate extract from Alocasia macrorrhiza to A549, B16, BGC-823 were 94.6, 541.9,629.5 μ g * ml-1 respectively, and those of the acetone extract from Alocasia macrorrhiza to A549 and B16 40.9,438.0 μ g * ml-1 respectively. But there were quite large dosages of the IC50 of the extracts of cyclohexane, benzine, ethyl alcohol and water from Alocasia macrorrhiza to all kinds of cell lines. The obvious acute toxicities were not observed for the ethyl acetate and acetone extracts of Alocasia macrorrhiza under the treatment doses of 60g * kg