Dingxuan mixture of inadequate blood supply to vertebrobasilar artery in rabbit brain norepinephrine 5 - HT and hemorheology.docVIP

 PAGE \* MERGEFORMAT 15 Dingxuan mixture of inadequate blood supply to vertebrobasilar artery in rabbit brain norepinephrine 5 - HT and hemorheology Of: Zhang Guohua, INTEGRATED, Liyan Yi, Qiao Chengdong, in Yan, Yuan mm [Abstract] Objective To observe the effect of Dingxuan mixture (Dingxuanheji) in rabbit basilar artery insufficiency (VBI brain norepinephrine (NE, 5 - hydroxytryptamine (5-HT levels and blood rheology. Methods health bruising election Portland 40 rabbits were randomly divided into blank group, model group, flunarizine group Dingxuan mixture of high and low dose group, n = 8, except the blank group, other groups with high fat diet and injection sclerotherapy, 7 d Repeat 1, 6 weeks after the successful model, and then continuously to the appropriate drugs were sacrificed after 4 weeks, the index determination. Results Dingxuan mixture can vertebrobasilar insufficiency animal brain tissue NE ,5-HT content increased, and key indicators to lower blood rheology, reducing the possibility of thrombosis. Conclusion Dingxuan mixture can improve the content of NE ,5-HT, through the improvement of ventilation conditions on the VBI has a protective effect in brain tissue and can improve the blood rheology , hemorheology can reflect the level of vertebral basilar insufficiency and the therapeutic effect of the extent of disease. [Keywords:] Dingxuan mixture, vertebral - basilar artery insufficiency, norepinephrine, 5 - HT Abstract: ObjectiveTo study effects of DXHJ on the NE ,5-HT contents of Brain Tissue and blood rheology in Vertebro-basilar Artery insufficiency model rabbits. Methods40 rabbits were randomly divided into 5 groups, normal group, model group, Flunarizine group and DXHJ high , low dose groups. Except normal group, the rest were fed by high fat diet, and injected Yinghuaji once a week for six weeks. Ten weeks later, the rabbits were sacrificed and the chose targets were tested. ResultsThe DXHJ could raise the cortents of monoamin