Disulfiram-like reaction causes and nursing care.docVIP

 PAGE \* MERGEFORMAT 6 Disulfiram-like reaction causes and nursing care [Keywords:] disulfiram-like reaction Keywords: disulfiram-like reaction; cause analysis; Nursing Disulfiram-like reaction is a drug-induced acute, also known as disulfiram-like, or disulfiram-like reaction [1]. By can cause disulfiram-like reaction of the interaction of drugs and alcohol. Our hospital emergency department in March 2003 ~ March 2005 a total of admissions caused by alcohol disulfiram-like reaction cases, 38 cases cured and discharged by the emergency rescue. Now the etiology and nursing experience are summarized below. A clinical data 38 cases, male 30 cases, 8 females, aged 23 years old ~ 49 years old, with an average age of 38 years. 28 cases of drinking alcohol during intravenous infusion of cefoperazone, 5 cases of cefazolin during intravenous infusion of alcohol, two cases of drinking alcohol during intravenous infusion of metronidazole and 3 patients cefoperazone for the disabled after 1d ~ 3d in drinking. 2 cause disulfiram-like reaction Cause Analysis 2.1 The staff of the disulfiram-like reaction to lack of knowledge 2.1.1 of the disulfiram-like reaction in the pathogenesis do not understand: Disulfiram is an alcohol of drugs, alcohol, after taking the drug, even drinking a small amount would cause serious physical discomfort, to achieve the purpose of drinking. Disulfiram mechanism of action is to inhibit liver aldehyde dehydrogenase, resulting in an intermediate metabolite of alcohol metabolism of acetaldehyde blocked, resulting in accumulation of acetaldehyde in the body and produce a series of reactions. At present, this enzyme also can not be determined through the laboratory. Some drugs can inhibit aldehyde dehydrogenase and disulfiram caused a similar reaction, clinically referred to as the disulfiram-like reaction. 2.1.2 Disulfiram-like reaction on the clinical features do not understand: In recent years, with the cephalosporins, nitroimidazole antibi