DN Tongluo yishentang on renal tissue of rats the expression of -SMA in rats.docVIP

 PAGE \* MERGEFORMAT 11 DN Tongluo yishentang on renal tissue of rats the expression of -SMA in rats Of: Dong Zhenghua, Yang Bo salary should Xiaoping, Song Chunguang, FAN Li, Li will [Abstract] Objective To observe Tongluo kidney on diabetic nephropathy (DN renal tubular epithelial and interstitial smooth muscle actin (@-SMA expression, and explore the side of the DN model of the renal protective effect mechanisms. Methods unilateral nephrectomy + STZ induced rat model of DN, rats were randomly divided into normal, Pathology, Tongluo kidney treatment group, western medicine group. observed after treatment of rats renal function (BUN, Scr , 24 h urinary protein (24hUpr, urinary 2-microglobulin (2-MG levels, kidney hypertrophy index and kidney @-SMA expression and other indicators. Results Compared with the pathology, kidney treatment group through a large network rat kidney index, BUN, Scr significantly improved (P lt;0.01,24 h Upr, urinary 2-MG decreased significantly (P lt;0.01, renal tubular epithelial and mesenchymal @-SMA expression was significantly decreased (P lt;0.01, and Western medicine group, all showed no significant difference (Pgt; 0.05. Conclusion Tongluo yishentang possible by reducing the renal tubular epithelial @-SMA expression, inhibition of renal tubular epithelial - mesenchymal transdifferentiation, tubulointerstitial delay fibrosis, thereby to protect the kidneys, the purpose of improving renal function. [Keywords:] diabetic Tongluo yishentang @ - smooth muscle actin Diabetic nephropathy (DN diabetes (DM developed to a certain stage of one of the main complications arise. DN continuous, progressive development, and will result in end-stage renal disease (ESRD). Renal interstitial fibrosis and the main reason leading to ESRD common pathological process of renal tubular epithelial - mesenchymal transdifferentiation (EMT of renal interstitial fibrosis is an important mechanism of pathogenesis [1], tubulointerstitial @ - smooth m