DNA damage and repair with platinum-resistant Progress.docVIP

 PAGE \* MERGEFORMAT 6 DNA damage and repair with platinum-resistant Progress [Abstract] platinum-group of non-small cell lung cancer of essential medicines, and its resistance mechanism to the complex, including DNA damage and repair capacity to change is an important platinum-resistant molecular basis. Full-text Summary DNA damage repair mechanisms - base excision repair, nucleotide excision repair enzyme DNA double-strand break repair and restoration research. [Keywords:] DNA damage repair XPD ERCC1-resistant DNA damage and repair is to restore the normal DNA sequence structure and maintain a relatively stable genetic information related to cellular responses. Repairable DNA damage and repair gene of the DNA damage caused by different reasons, to protect the integrity of genetic information. DNA damage and repair are four kinds of basic forms, namely, base excision repair, nucleotide excision repair enzymes repair and double-strand break repair. A base excision repair Base excision repair (base excision repair, BER) removal and replacement by the chemicals in the role of endogenous DNA base damage generated. DNA glycosylase involved in this process, followed by sugar phosphate bond rupture, trim base residues, DNA damage repair connection. The genes involved in BER are mainly X-ray repair cross-complement gene (X? Juan ray repair cross? Juan complementry gene, XRCC1), DNA ligase hOGG1, MPG, APG, APE1 [2]. XRCC1 was first isolated from mammalian cells against ionizing radiation-sensitive genes, located on 19q13.2, a size of 32 kb. XRCC1 and DNA polymerase β , DNA ligase Ⅲ interactions involved in base excision repair. XRCC1 gene defect sensitivity of cells to DNA damage, single-strand breaks increase the rate of sister chromatid exchange (SCE) than normal cells more than 10 times higher. DNA repair capacity and XRCC1 399Arg/Gln genes related to changes in phenotype, there XRCC1 399 polymorphism in NSCLC patients to platinum-resistant [3,4], and this is