Domestic cetirizine hydrochloride existence of discrete human pharmacokinetics and relative bioavailability of.docVIP

 PAGE \* MERGEFORMAT 5 Domestic cetirizine hydrochloride existence of discrete human pharmacokinetics and relative bioavailability of Abstract Objective: To study the domestic cetirizine hydrochloride tablets in healthy volunteers Pharmacokinetics and relative bioavailability. Methods: 8 healthy male volunteers, using reversed-phase high performance liquid chromatography with ultraviolet detection wavelength of 229 nm as determined by a single dose (10 mg) of oral cetirizine hydrochloride domestic and imported tablets Cetirizine Hydrochloride tablets in the human body the concentration of cetirizine. Results: Cetirizine hydrochloride was a dynamic process in vivo absorption of two-compartment open model, Chinese-made films and imported films cmax = (316.71 ± 39.66) and (314.80 ± 31.79) ng / ml, tmax were (0.72 ± 0.09) and (0.72 ± 0.09) h, t1/2β were (10.71 ± 3.06) and (9.95 ± 2.41) h, AUC0 ~ ∞ , respectively (2 728.52 ± 356.06) and (2 753.01 ± 360.33) ng * h / ml. Conclusion: Domestic cetirizine hydrochloride tablets relative bioavailability (99.50 ± 8.89)%; select cmax and AUC0 ~ ∞ for three-way ANOVA and two one-sided t test results showed that the two kinds of Chinese-made films and imported films formulations are bioequivalent. Keywords:: cetirizine hydrochloride; pharmacokinetics; bioavailability Cetirizine (cetirizine) is the first-generation antihistamines hydroxyzine activity of carboxylic acid derivatives, the molecular structure of the amphoteric characteristics of the central inhibition to no obvious clinical primarily for prevention and treatment of allergic rhinitis, chronic idiopathic onset urticaria, allergic diseases such as asthma and atopic dermatitis [1,2]. At present, the cetirizine hydrochloride clinical pharmacokinetic data, foreign scholars have conducted numerous studies involving newborns, infants, children, youth, elderly and some clinical cases of different groups [3 ~ 7]. Developed the first pharmaceutical factory in Ji