Drug Challenge Test (pharmacological pain mechanisms for identification test)- a powerful weapon to deal with Neuropathic Pain.docVIP

 PAGE \* MERGEFORMAT 4 Drug Challenge Test (pharmacological pain mechanisms for identification test): a powerful weapon to deal with Neuropathic Pain Pain is the body of a physiological phenomenon of self-protection: it warns us to avoid those risks tissue damage. When the inevitable injuries, injuries lead to peripheral and central nervous system to produce changes in excitability, so feel the pain in the body, resulting in a number of actions and the corresponding reflex to avoid injury, the meantime, because of pain, the body will always be to avoid similar The noxious stimulation until the tissue to heal. However, when the pain persisted, these benefits have disappeared biology and vice versa for patients bring great physical and mental pain and trauma. This pain is often due to malignant peripheral nerve, dorsal root ganglia, dorsal root, as well as direct injury to the central nervous system, causing a number of susceptible people produce negative symptoms such as feeling of partially or completely missing, as well as positive symptoms such as spontaneous pain, perception of incomplete I feel bad, allodynia, pain, allergies, etc. This is known as neuropathic pain (Neuropathic) Pain [1,2]. Despite the pain by itself is a kind of spiritual feeling of experience, because it causes a different, often divided into invasive (nociceptive), inflammatory and neuropathic pain [2]. Disappears when the injury against the pain stimulus would be dissipated, the same, despite the inflammatory nature of the pain will last a few hours to several days, this pain is reversible, the ultimate feeling of the nervous system will resume normal [2]. However, neuropathic pain, but because the pathological changes in the nervous system may be life-long unhealed. Neuropathic pain etiology, pathogenesis and symptoms of a very complex relationship between the so far unknown.Shown by different diseases may play in pain on the same mechanism; a specific disease process is not a defini