糖尿病英文PPT课件.ppt

Diabetes Mellitus;Diabetes Mellitus;Definition-WHO (4/2000);Definition;Diabetes Mellitus;Aetiological Classification of Disorders of Glycaemia;Type 1 diabetes;Type 1 diabetes mellitus;Type 1 diabetes mellitus;Type 1 diabetes;Type 1 diabetes mellitus usually autoimmune destruction of insulin-producing pancreatic islet ? cellsover months absolute insulin deficiency rapid presentation withthirst, polyuria, weight loss, blurred visionthrush, lethargy, dizziness. nausea, vomiting, abdominal cramps, and superficial infection usually thin and ketotic at presentation Auto-antibodies identified: anti islet cell (ICCA. ICSA), anti GAD(64KD), anti Insulin (IAA) ;A progressive metabolic disordercharacterised by:;Type 2 diabetes;Type 2 diabetes Underlying insulin resistance genetic and ethnicity Obesity BMI WHR inactivity / low physical fitness intrauterine childhood factors smoking drugs Impaired insulin secretion Insulin secretion worsens with time;Type 2 diabetes;Pancreatic ?-cell ;Tissue Responses to InsulinResistance or Failure;MUSCLE;ADIPOSE;Insulin resistance and insulinhypersecretion precede type 2 diabetes;Clinical Reavans Syndrome;abdominal obesity;Type 1 diabetes typical onset 30 years can start at any age sudden onset severe symptoms recent weight loss usually thin spontaneous ketosis absent C-peptide markers of autoimmunity;Diabetes in pregnancy co-existent or newly diagnosed lifelong diabetes type 1 type 2 (especially in South Asian women) other specific types of diabetes gestational diabetes;Other types of Diabetes;Types-continued;Pathophysiology;Diabetes Mellitus;Symptoms of diabetes due to hyperglycaemia;;Symptoms of diabetes due to hyperglycaemia;Diabetes Mellitus;ADA diagnostic criteria (1997);WHO diagnostic criteria;Changes from Old criteria;Diagnosis of diabetes symptoms + elevated blood glucose level OR elevated blood glucose levels on two occasions ;Differential Diagnosis;Diabetes Mellitus;;Laboratory findings;Diabetes Mellitus;Treatm