Edaravone on myocardial oxygen free radical damage in the rat and human viral myocarditis Antioxidation.docVIP

Edaravone on myocardial oxygen free radical damage in the rat and human viral myocarditis Antioxidation.doc

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Edaravone on myocardial oxygen free radical damage in the rat and human viral myocarditis Antioxidation

 PAGE \* MERGEFORMAT 13 Edaravone on myocardial oxygen free radical damage in the rat and human viral myocarditis Antioxidation [Abstract] Objective edaravone oxygen free radicals in the rat (OFR) myocardial damage and human viral myocarditis (VMS) in antioxidant activity. Method by detecting the cell culture medium myocardial viability of myocardial cells (CMV) , superoxide dismutase (SOD), malondialdehyde (MDA), troponin T (cTnT) indicators to compare edaravone, vitamin C and coenzyme Q10 on myocardial preconditioning by oxygen free radicals protect cells . Detection of serum levels SOD, MDA, cTnT indicators for comparison of edaravone, vitamin C and coenzyme Q10 for the treatment of patients with VMS. Results (1) rats showed: CMV edaravone group than vitamin C group (P lt;0.05) and coenzyme Q10 group (P lt;0.05), SOD activity than vitamin C (P lt;0.05); MDA lower than the vitamin C group (P lt;0.05) and the coenzyme Q10 group (P lt;0.05); cTnT low in the vitamin C group (P lt;0.05) and the coenzyme Q10 group (P lt;0.05). (2) VMS research shows: After treatment, edaravone group than in patients with SOD activity increased vitamin C and coenzyme Q10 group group (all P lt;0.05); MDA and decreased cTnT than vitamin C and coenzyme Q10 group group (MDA both P lt;0.01, cTnT were P lt;0.05). Conclusion OFR edaravone in rat myocardial damage and antioxidant therapy VMS There are obvious results. [Keywords:] edaravone; oxygen free radicals; viral myocarditis ABSTRACT Objective To study the anti-oxygen effect of edaravone on the injured myocardial cells of rats by oxygen free radicals (OFR) and on those of patients with viral myocarditis. Methods The detected index of cardiomyocytes viability (CMV), superoxide dismutase (SOD) , malondialdehyde (MDA) and troponin T (cTnT) of the injuried myocardial cells of rats by OFR were applied in the comparative observation of the protective effect of edaravone, Vitamin C and coenzyme Q10 on the myocardial cells pre-prepar

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