EB virus latent membrane protein 1 and tumor metastasis progress of the study.docVIP

 PAGE \* MERGEFORMAT 16 EB virus latent membrane protein 1 and tumor metastasis progress of the study [Keywords:] EB virus latent membrane protein 1 tumor metastasis EB virus (Epstein  Barr virus, EBV) and Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s disease and other closely related. EB virus-encoded a variety of proteins, in which EB virus latent membrane protein 1 (Latent membrane protein  1, LMP1) the only recognized as having the cancer gene function in selling scholars are concerned about. Transfer is the most basic biological characteristics of malignant tumors, but also a key factor affecting the prognosis of patients. The same kind of tumor, LMP1-positive than negative expression to express it easier for tumor invasion of adjacent normal tissue and transfer to the lymph nodes, LMP1 with the tumor metastasis in various stages of the process of the many factors related to the regulation through a series of complex and promote tumor metastasis. 1 LMP1 gene and protein Encoded LMP1 gene is located in EB virus genome in U5  TR zone BNLF  1 gene transcription, 2.8kb of the mRNA, translation of the size of the LMP1 protein synthesis 62KD. LMP1 protein is a 386 amino acid residues of a complete transmembrane protein, is divided into three sections: amino-terminal cytoplasmic domain of 24 amino acid residues, followed by a hydrophobic transmembrane structural areas, there are six transmembrane domain and 5 to connect the ring structure (3 extracellular, intracellular 2), and finally by the 200 amino acid residues with the signal transduction-related carboxyl-terminal cytoplasmic domain. LMP1 transmembrane domain to anchor the cell membrane, the N-terminal and carboxyl-terminal alienation from the cytoplasm. Carboxyl-terminal region is a major functional areas, there are three important domains: 194 ~ 231 amino acids between the CTAR1 (Carboxyterminal activating region1), and tumor necrosis factor receptor signaling associated factor 2 (