Elderly patients with chronic hepatitis B Immunology.docVIP

 PAGE \* MERGEFORMAT 14 Elderly patients with chronic hepatitis B Immunology On: Jun-Qi Niu Wang Dongsheng Jiang Yanfang Keywords: Aged; hepatitis B; Immunology Hepatitis B (HB) is a worldwide epidemic of infectious diseases. It is estimated that about 20 million people worldwide have been infected with HB virus (HBV), chronic infection of about 3.5 to 4 million people, 100 million people each year die from HBV-induced liver cirrhosis, liver failure and primary liver cancer 1. HB of the high rate of HBV infection rate of about 9.09% of the population 2, HB has become a serious social problem. HBV infection and the immune state is closely related to HBV infection in childhood, about 90% develop into chronic infection, and youth and adult infection, only 10% develop chronic infection. With aging, surgery and blood transfusion more opportunities, as well as organ-specific changes in the elderly, leading to opportunities for elderly patients with chronic HBV infection was significantly increased. 1 HBV features HBV is hepatotropic DNA viruses, the complete virus particle as Dane particle diameter of 42 nm, the double-shell and a core component. Core diameter of 27 nm, containing circular double-stranded DNA, DNA polymerase, core protein 3. Outside the envelope protein, a thickness of 7 nm, the surface antigen. Its genome from the S Zone, C Zone, X zone and P zone. S area code before the S1 protein, the former S2 protein and hepatitis B virus surface antigen (HBsAg). Before the S protein has a strong immunogenicity. In HBV attachment and invasion mechanisms of the host liver cells plays an important role. S1 and S2 before the protein can lead to the former host and regulation of humoral and cellular immune responses, for the removal of the virus in body fluids and prevent the virus from infected healthy liver cells provide an important immune defense mechanism. C, and C by the former C gene genetic makeup, the former C gene encodes a prot