Elderly patients with chronic heart failure and tumor necrosis factor- levels of brain natriuretic peptide and left ventricular function studies.docVIP

 PAGE \* MERGEFORMAT 8 Elderly patients with chronic heart failure and tumor necrosis factor- levels of brain natriuretic peptide and left ventricular function studies [Abstract] Objective To investigate the chronic heart failure (CHF) in patients with serum levels of tumor necrosis factor-@ (TNF @ and brain natriuretic peptide (BNP) levels and left ventricular function. Methods 50 cases were determined by ELISA elderly patients and 50 elderly patients with CHF healthy controls the concentration of serum TNF @ and BNP, echocardiography subjects with left ventricular parameters. Results The plasma TNF @ CHF and BNP concentrations were higher, and with the severity of heart failure increased significantly (P lt;0.05), CHF, and BNP plasma concentrations of TNF @, respectively, and left ventricular end diastolic diameter was positively correlated (P lt;0.05), but not with left ventricular ejection fraction and left ventricular shortening fraction was negatively correlated (P lt;0.05), and TNF @ and the BNP was a significant positive correlation between (P lt;0.05). Conclusion Serum TNF @ in CHF play an important role in the development of joint detection of TNF @ and the BNP will help determine the severity of CHF, the effective inhibition of inflammatory cytokine treatment of CHF is expected to become the new means. [Keywords:] Chronic heart failure, tumor necrosis factor-@, brain natriuretic peptide, left ventricular function Existing research suggests that, in chronic heart failure (CHF in progress, in addition to abnormal neurohormonal activation, the increase of cytokines also play an important role (1). Heart failure in patients with tumor necrosis factor-@ (TNF @ and other inflammatory markers were significantly increased, and the severity of heart failure was directly proportional to indicate poor prognosis in patients with heart failure (2). In this study, serum TNF @ elderly CHF patients and brain natriuretic peptide (BNP) level and the relevance