Elderly patients with diabetes and pancreaticcell function and amylin and the relationship between melatonin.docVIP

 PAGE \* MERGEFORMAT 11 Elderly patients with diabetes and pancreaticcell function and amylin and the relationship between melatonin Study: Mali Chuan Lin Aiqing LI Ming-long Chen Haiyan Zhao Shue Liu industry [Abstract] Objective To observe newly diagnosed elderly diabetic (DM characteristics of patients with pancreatic cell function and its relationship with amylin, the relationship between melatonin. Methods 60 patients with newly diagnosed DM, of which 27 cases of elderly DM group, 33 cases of adult DM the control group of 30 cases. underwent oral glucose tolerance test (OGTT, calculated -cell function index (HOMA . by ELISA assay in patients with fasting serum amylin, melatonin levels. simultaneous determination of blood of all subjects, body mass index (BMI and waist to hip ratio (WHR, and the results were analyzed statistically. Results (1 older adult DM group and DM group was significantly lower HOMA ((58.20 + -24.89) vs (81.20 + -40.80), P lt; 0.01), while the OGTT 2 h glucose, insulin and insulin resistance index (HOMA IR was significantly higher (P all lt;0.05. (2 compared with the control group, elderly DM serum amylin levels were significantly higher ((21.57 + - 15.88) vs (17.82 + -12.15) ng / L, P lt;0.01), and melatonin levels were significantly lower ((6.56 + -1.32) vs (7.65 + -1.39) pg / ml, P lt;0.01). (3 HOMA aged diabetes group was positively correlated with melatonin (r = 0.403, P = 0.016), and amylin (r =- 0.461, P = 0.003), HOMA IR (r =- 0.238, P = 0.009) were negatively correlated with fasting plasma glucose, insulin, triglyceride (TG), WHR was no significant correlation. Conclusions of newly diagnosed DM in elderly patients with significant defects in insulin secretion, the increase of amylin and melatonin may be associated with old age the occurrence of diabetes. [Keywords:] diabetes, old age, -cell function, amylin, melatonin Elderly diabetes mellitus (DM and DM compared with adult onset occult, the symptoms are not typ