Electroacupuncture in rats with vascular dementia and hippocampal long term potentiation of calmodulin calmodulin-dependent protein kinasemRNA expression levels of.docVIP

 PAGE \* MERGEFORMAT 16 Electroacupuncture in rats with vascular dementia and hippocampal long term potentiation of calmodulin calmodulin-dependent protein kinasemRNA expression levels of Of: Li Min, Xu Guofeng, Wan Lai Siqi [Abstract] [Objective] To investigate the power for vascular dementia (VD) rats with long-term potentiation (LTP) and calmodulin (CaM), calmodulin-dependent protein kinase (CaMPK ) mRNA expression levels of . [Method] 70 SD rats, in addition to the normal group, sham operation group 14, the other 4 VO method modified after 36 successful model were divided into acupuncture group, western medicine group, model group 12. Acupuncture Baihui EA group, Ojo, Shenshu, western group was given nimodipine 12 mg kg-1 d-1, the other 3 groups untreated. observed the rats escape Morris water maze latency the quadrant platform across the number of in vivo hippocampal LTP experiments and neuronal CaM, CaMPK mRNA expression. [Results] Compared with model group, EA group and western medicine group escape latency was shorter across the original platform and on the left platform, increase the number of , LTP amplitude increased, duration, CaM, CaMPK mRNA expression was significantly increased (all P lt;0 05). [Conclusion] VD EA improve learning and memory in rats may be related to able to increase the role of response amplitude and duration of LTP, increased CaM, CaMPK mRNA expression levels related. [Keywords:] vascular dementia / acupuncture therapy; disease models, animal; rat; Point, Baihui; Point, Ojo; points, Shenshu Vascular dementia (vascular dementia, VD) mainly due to cerebral vascular factors in the brain tissue from blood circulation, brain function decline as a result of the syndrome of cognitive impairment [1]. Long-term potentiation (long term potentiation, LTP) and learning and memory are closely related, most of the factors that affect the LTP impact on learning and memory, a number of factors affect the learning process of L