Endogenous cannabinoid system and mechanism of neuroprotection.docVIP

 PAGE \* MERGEFORMAT 20 Endogenous cannabinoid system and mechanism of neuroprotection Cannabis is an ancient cultivated plants. For centuries it has been as a treatment for a variety of diseases, the use of herbs. Now people have come to realize its prospects for application in medicine and the importance of, and embarked on a mechanism of cannabinoid substances and medicinal value of research. A large number of animal experiments show that cannabinoid substances with analgesic, sedative, anti-spasm, anti-vomiting, anti-glaucoma, anti-convulsive and anti-myocardial ischemia-reperfusion injury in a variety of pharmacological effects [1]. Based on existing research reports, on the endogenous cannabinoid system and its neuroprotective effects are reviewed in order to more clearly understand the cannabinoids in nerve protection pharmacological effect and clinical significance. A cannabinoid Introduction The active compounds of cannabis known as cannabinoids (cannabinoids). Cannabis contains a variety of active ingredients, of which △ 9 - tetrahydrocannabinol (△ 9-tetrahydrocannabinol, △ 9-THC) the main. The role of THC on the human body include euphoria, drowsiness, short-term memory impaired, short-term orientation of functional disorders. Higher doses of THC would lead to hallucinations and delirium, while the euphoria will be replaced by anxiety. THC on the other systems also have a wide range of effects, such as respiratory impairment, tachycardia, and blood pressure changes [2] [3]. At present, the cannabinoids for clinical therapeutic effect of drugs is very broad, including treatment of nervous system diseases, cardiovascular diseases, glaucoma, alcoholism; antiemetic; stimulate the appetite; anti-asthma; antibacterial [3] [4]. 2 endocannabinoids system 2.1 endocannabinoids [5] Was first isolated and identified endocannabinoids are Anandamide and 2-AG. Raphael Israeli in 1992, research for the first time extracted fr