Endometrial papillary serous adenocarcinoma of the progress.docVIP

 PAGE \* MERGEFORMAT 17 Endometrial papillary serous adenocarcinoma of the progress [Abstract] Endometrial papillary serous carcinoma (UPSC) of endometrial cancer is a special type of unique biological behavior, high degree of malignancy, treatment difficulties and poor prognosis. The low rate of clinical diagnosis, pathogenesis is not yet clear, treatment options are still being explored. endometrial glands present dysplasia (EmGD) is a precancerous lesion of UPSC has the relevant knowledge, which is early diagnosis and prevention of the future play a guiding role in disease . In addition, with further research, more and more molecular markers will gradually been recognized, the molecular targeted therapy will also bring hope to the treatment of UPSC. UPSC now on the cause and pathology, molecular markers and related treatment are reviewed. [Keywords:] UPSC; etiology; precursor lesions; molecular markers; targeted therapy Papillary serous adenocarcinoma of the endometrium (uterine papillay serous carcinoma, UPSC) is a special kind of endometrial cancer histological type, the incidence rate of endometrial cancer from 1% to 10% [1,2], age of onset 65 ~ 72 years. In the classification of endometrial cancer, UPSC did not express estrogen and progesterone receptors (ER, PR), often occurs in the shrinking or static endometrial histology on the UPSC and clear cell carcinoma Dengjun belongs to type Ⅱ cancer. The highly malignant, highly invasive, early extrauterine metastasis prone to peritoneal dissemination in the highest. Since this disease is difficult to collect clinical cases, this study is not sufficient, at home and abroad in recent years, mainly from precursor lesions, etiology, pathology, molecular markers and gene expression, combined treatment and prognosis aspects expand research [3]. 1 Causes and risk factors Many authors suggest that obesity, diabetes, hypertension, infertility, delayed menopause are estrogen-dependent factors such as ris