Endothelial nitric oxide synthase gene polymorphism and ischemic cerebrovascular disease in Ningxia Correlation Analysis.docVIP

 PAGE \* MERGEFORMAT 11 Endothelial nitric oxide synthase gene polymorphism and ischemic cerebrovascular disease in Ningxia Correlation Analysis [Abstract]: Objective To study the endothelial nitric oxide synthase (eNOS gene polymorphism and population in Ningxia region between ischemic cerebrovascular disease. Methods Polymerase chain reaction (PCR) method, 596 healthy controls in Ningxia those, 468 patients with ischemic cerebrovascular disease of the eNOS gene intron 4 variable repeat polymorphism (VNTR genotype. Results of two populations eNOS gene intron 4 VNTR showed eNOS4a/4a, eNOS4a/4b, eNOS4b/4b 3 genotypes. ischemic stroke in patients with aa genotype 2.7%, ab genotype frequency of 18.7%, bb genotype frequency was 78.6%; aa genotype in the control group was 1.2%, ab genotype frequency of 13.6%, bb genotype frequency of 85.2%. a allele frequencies in patients and control groups were 12.1% and 8.0%, by 2 test, a genotype frequency between the two groups allele frequency difference was statistically significant (2 = 9.122, P = 0.010, 2 = 10.008, P = 0.002). Conclusion eNOS4a gene carrying the crowd with the Ningxia region the occurrence of ischemic cerebrovascular disease were associated with. [Keywords:] Endothelial nitric oxide synthase, gene polymorphism, ischemic cerebrovascular disease Abstract: Objective To investigate the relation between endothetial nitric oxide synthase (eNOS gene polymorphism and cerebral ischemic stroke patients of Ningxia. Methods A case-control study was performed to determine whether the variable number of tandem repeats (VNTR) polymorphism of eNOS gene were associated with cerebral ischemic stroke. The VNTR polymorphism of eNOS gene was analyzed with PCR in 468 patients with cerebral ischemic stroke group and 596 healthy subjects group from Ningxia population, Results Involved in this study, VNTR4 of eNOS gene showed 3 genetypes, named eNOS4a, eNOS4b and eNOS4a/4b. The frequencies of the three genetypes were as fo