Enterovirus 71 Molecular Biology.docVIP

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Enterovirus 71 Molecular Biology

 PAGE \* MERGEFORMAT 8 Enterovirus 71 Molecular Biology [Abstract] biological characteristics on the EV71 virus, the virus replication, diagnostic techniques, EV type identification and molecular epidemiology, etc. are reviewed. [Keywords:] genotype of enterovirus 71 Molecular Epidemiology Abstract: It makes review on EV 71 intestinal virus about its biological characteristic, replication, diagnosis technology, EV type identification and molecular epidemic science. Keywords:: intestinal virus; EV 71; gene type; molecular epidemic science In recent years, enterovirus 71 (EV71) infection in parts of the world emerging outbreak reported. EV7I infection mainly caused by hand-foot-mouth disease, but due to complications of the nervous system can lead to death or permanent muscle paralysis. This article from the EV71 virus, biological characteristics, the virus replication, diagnostic techniques, EV type identification and molecular epidemiology, etc. are reviewed. The general characteristics of a virus 1.1 The structure and physicochemical properties of virus-like particles enterovirus 71 (EV71) belongs to a small RNA virus family (Picornaradae) intestinal virus (Enterovirus) members [1]. EV71 virus particles for the icosahedral structure of three-dimensional spherical symmetry, no capsule, and processes in diameter about 24 ~ 30nrn, single-stranded nucleic acid strand of RNA. The composition of the virus capsid particles are very complicated, first by VPI, VPZ, VP3 and VP4 four kinds of coat protein composition of the original polymer (Protomer), then five of the original polymer assembled into a polymer-like structure with five subunits (Pentamer ). Of four structural proteins, in addition to VP4 embedded in the virus particles inside the shell in close connection with the virus core, other three kinds of structural proteins are exposed to the virus-like particles on the surface, which epitopes are mainly located in VPI.VP3 (see Figure 1). Because the vir

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