ERCC1 BRCA1 in non-small cell lung cancer and cisplatin resistance in Progress.docVIP

 PAGE \* MERGEFORMAT 13 ERCC1 BRCA1 in non-small cell lung cancer and cisplatin resistance in Progress [Keywords:] ERCC1 BRCA1 non-small cell lung cancer and cisplatin resistance Lung cancer is the most worldwide cancer mortality [1], according to pathological types, lung cancer diagnosed in about 80% of non-small cell lung cancer, newly diagnosed each year in the United States NSCLC, 75% of patients had surgical treatment can not be [2], chemotherapy and radiotherapy for these patients is the main method of treatment. but the tumor cells to chemotherapeutic drug resistance often lead to treatment failure. NSCLC tumor cells now based chemotherapy drug cisplatin resistance herbs and mismatch excision repair protein, the relationship between breast cancer susceptibility gene research status and prospects are reviewed. A mechanism of cisplatin Cisplatin cytotoxicity on tumor cells mainly through the formation of platinum-DNA adducts. The main targets of cisplatin is DNA, into the tumor cells after cisplatin hydrolysis to ammonia diclofenac double platinum, and then the formation of cisplatin with cellular DNA -DNA adducts affect cell DNA replication and transcription, leading to DNA damage [3]. cisplatin adduct formation of mainly 1 and 2 cross-linking between chains, accounting for 90%, a small number of 1, 3 chains crosslinking, long chain, and DNA2 protein cross-linking cross-linking. 2, mismatch excision repair protein 1 (ERCC1) 2.1 nucleotide excision repair Nucleotide excision repair (nucleotide excision repair, NER) is the cause of cisplatin resistance in an important mechanism. NER is an important way to DNA repair, which repair DNA damage in the bulk play an important role [4], including UV dimers, polycyclic aromatic hydrocarbons, and other heavy metals in cisplatin-induced DNA damage. NER pathway is a complex process, involving more than 30 peptides, NER proteins can be divided into two groups: one group was DNA damage identificatio