Erythropoietin (EPO) in liver ischemia-reperfusion injury (HIRI) The role of.docVIP

 PAGE \* MERGEFORMAT 6 Erythropoietin (EPO) in liver ischemia-reperfusion injury (HIRI) The role of Good blood circulation is to organize cells in adequate supply of oxygen and nutrients and remove metabolic products of the basic guarantee. Tissues and organs caused by various reasons, the blood perfusion is often reduced ischemic damage, while the ischemic tissues, organs, blood flow through the recovery after reperfusion not only failed to restore its function and structure, but to increase its dysfunction and structural damage of the phenomenon known as the ischemia - reperfusion injury (ischemi-a-reperfusion injury). Hepatic ischemia-reperfusion injury (Hepatic ischemia reperfusion injury HIRI) is very important during liver surgery complications, a number of major surgery, especially the liver long liver transplant surgery there is often hepatic ischemia process [1], while the liver ischemia-reperfusion injury can also affect liver regeneration after liver resection and liver function recovery, therefore, how to carry out perioperative liver protection research, rational drug use, prevention of liver ischemia-reperfusion injury would have important clinical significance. Hepatic ischemia-reperfusion injury in the major mechanism of mainly (1) Oxygen free radicals: (2) the role of calcium overload injury; (3) apoptosis; (4), release of inflammatory mediators; (4) kupffer cell activation and neutrophil aggregation, adhesion and activation, to enhance endothelial cell adhesion [2]; (5), endothelin (ET) and nitric oxide (NO) concentration of imbalance; (6) the role of platelet-activating factor; ( 7) The micro-circulation disorders. HIRI is due to the interaction of various mechanisms, integrated effects. EPO (erythropoietin, EPO) to stimulate the bone marrow is a glycoprotein hormone, is a sialic acid-containing acidic protein. The human EPO gene is located in area 22, the long arm of chromosome 7, relative molecular weight of 34,000, there are four glycosy