Epidemic encephalitis IL-1 neuron-specific enolase and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 12 Epidemic encephalitis IL-1 neuron-specific enolase and its clinical significance Of: Stone Sea alum, Li Wei, Chen Yiping, Wang Hong Jiao, Zhang Guilian, Jinsheng Xin [Abstract] Objective?: Research encephalitis (JE) in children with cerebrospinal fluid, serum interleukin-1 (IL-1) and neuron specific enolase (NSE) and its clinical significance. Methods : 50 cases of encephalitis B patients in the observation group, Glasgow score divided by the normal group of 17 patients, 20 patients with mild and severe group of 13 patients. detect very period, recovery of cerebrospinal fluid and serum IL-1, NSE levels and 20 patients with non-central nervous system diseases in children were compared. IL-1 using double-antibody sandwich enzyme-linked immunosorbent assay, NSE using electrochemiluminescence assay. Results: The CSF of JE patients, serum IL-1 and NSE content in the most period of recovery are better than the control group was significantly higher (P all lt;0.01), and increased the degree of severity of parallel (P? lt;0.01). cerebrospinal fluid and serum IL-1 levels and the CSF and serum NSE levels were positively correlated ( P? lt;0.01), and NSE in cerebrospinal fluid content of IL-1 and IL-1 and NSE serum levels were also positively correlated (P? lt;0.01). Conclusion: The CSF and serum IL-1, NSE determination of encephalitis in children with cerebral injury and clinical disease has important reference value to judge. [Keywords:] interleukin-1; neuron-specific enolase; epidemic encephalitis; cerebrospinal fluid; serum Abstract:? Objective: To study the changes of interleukin-1 (IL-1) and neuron-specific enolase (NSE) both in cerebrospinal fluid (CSF) and serum in children with Japanese encephalitis and the clinical significance of the changes. Methods: ? Fifty cases of children with Japanese encepha-litis were observed, which were divided into three groups according to Glasgow score:? normal group (17 cases), general group? (2