Escitalopram and paroxetine in the treatment of depression controlled study starting_0.docVIP

 PAGE \* MERGEFORMAT 9 Escitalopram and paroxetine in the treatment of depression controlled study starting [Abstract] Objective escitalopram and paroxetine in the treatment of first-episode depression, clinical efficacy and safety. Methods 76 first episode of depression were randomly assigned to escitalopram group (treatment group and the paroxetine group ( the control group for 8 weeks. with Hamilton Depression Rating Scale (HAMD before and after treatment in the treatment of 1,2,4,6,8 weeks to assess the clinical symptoms of adverse reactions with the scale (TESS assessment of adverse reactions. Results first week of treatment, the second weekend, escitalopram group HAMD scores were lower than the paroxetine group, two scores were significantly (P lt;0.05, and in section 4,6,8 weekend HAMD scores between the two groups were not statistically significant. 8 weeks of treatment, the escitalopram group was 92.1%, markedly effective rate 86.8%, paroxetine group were 92.1%, 84.2%. no difference between the two groups statistically significant. In terms of adverse reactions, no significant difference between the two groups. Conclusion escitalopram and paroxetine in the treatment of depression starting very effective, fewer side effects, safety is good. but from escitalopram faster onset, is conducive to quickly relieve symptoms. [Keywords:] escitalopram, paroxetine, episode depression Depression is a common mental illness, social problems caused by more and more attention, the World Health Organization predicts that by 2020, it could become the second largest illness after heart disease [1]. The traditional treatment of depression disease drugs is small, but because of side effects, poor compliance and the reasons for the treatment of depression has been limited. escitalopram, as a new antidepressant drug, its unique mechanism of action, a significant effect [2,3] attentions. but few reports of domestic-related. This study escitalopram and paroxetine in th