Esmolol on the ventricular action potential and Ltype calcium channels in.docVIP

 PAGE \* MERGEFORMAT 9 Esmolol on the ventricular action potential and Ltype calcium channels in Of: Lu Yang Shu-Mei Zhang Wenjie Zhang Xiaohao Abstract Objective esmolol in guinea pig ventricular myocytes (AP) and L type calcium ion channels. Methods Langendorff isolated heart perfusion reverse separation in guinea pig ventricular myocytes, ventricular myocytes were selected randomly divided into control and esmolol (50 mol / L and 100 mol / L) group. Application of whole-cell current-clamp mode to record ventricular AP, applied voltage-clamp mode to record L type calcium channel current (ICa L). Results esmolol (100 mol / L) AP myocardial cells can schedule APD20, APD50 was shorter (P lt;0.05), ventricular myocytes ICa L significantly reduced the peak current (P lt;0.05). Conclusion esmolol shortened AP duration of ventricular myocytes and inhibits calcium channel may be the mechanism of inhibition of the sympathetic storm. Keywords: esmolol; myocardial cytology; action potential; calcium channel, L-type Sympathetic storm is within 24 h onset of 2 or more than 2 ventricular tachycardia or ventricular fibrillation. Its root cause is excessive sympathetic nervous excitement, resulting in recurrent ventricular tachycardia and ventricular fibrillation, a number of times the electrical cardioversion. In recent years, -blockers found in supraventricular arrhythmias not only effective, but also effectively inhibit the sympathetic storms repeatedly caused ventricular tachycardia, ventricular fibrillation 1. Esmolol (Esmolol) for the ultra-short effect, with the heart of a selective 1 blocker, a variety of supraventricular arrhythmias have a significant effect, with a short half-life, clearance rate, rapid onset, no accumulative advantages 2,3, but the ion channels in ventricular myocytes of the mechanisms are still no reports. This study aimed to investigate the myocardial cells of esmolol on the mechanism of ion channels. 1 Materials and m