Esomeprazole diseases of the digestive tract.docVIP

 PAGE \* MERGEFORMAT 12 Esomeprazole diseases of the digestive tract [Keywords:] esomeprazole digestive diseases Helicobacter pylori On the treatment of acid-related diseases are primarily used acid-suppressing drugs, one histamine-H2 receptor antagonists, and the other is a proton pump inhibitor (PPI) [1], PPI’s widely used, many acid-related diseases been a very good treatment. L omeprazole, the trade name Nexium (Nexium) in China has been more than 3 years clinical history, with a strong acid-suppressing effect. pharmacokinetic now , acid-suppressing ability, combined with eradication of Helicobacter pylori (HP) and clinical efficacy of such drugs are summarized below. 1 esomeprazole pharmacokinetics and acid-suppressing ability Esomeprazole up by the CYP3A4 metabolic pathway, dependent on the CYP2C19 small. By CYP2C19 and 3A4 metabolism of the ratio is about 3:1, less than other PPI (6:1), therefore more stable clinical efficacy [2]. Egypt La azole drugs Somerset area under the curve (AUC) greater peak plasma concentration (Cmax) was significantly higher than other PPI, 40mg and 20mg of its area under the curve of omeprazole 20mg, respectively 5 and 2 times [3]. metabolic advantage of the acid-suppressing effect of esomeprazole stronger, more stable clinical results [4]. esomeprazole in fast metabolizers and slow metabolizers of patients in the acid-suppressing effect in patients with no significant difference in [ 5], oral esomeprazole in 4h can be reached within the gastric juice pH, 4.3, pHgt; 4 for significantly longer than rabeprazole, and rapid onset, longer-lasting acid suppression in the treatment of 1 day intragastric pH on day 5 were significantly higher than the median value of the rabeprazole [5]. It has been reported [6], oral administration of esomeprazole 40mg, 2 times a day, the treatment of gastric juice pH up to 6.4 after 24h, while Oral pantoprazole 40mg, 2 times a day, 24h after treatment pH value of 5.1, the former pHgt; 4 o