Esophageal cancer patients CD4 + CD25 + Foxp3 + regulatory T cells and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 10 Esophageal cancer patients CD4 + CD25 + Foxp3 + regulatory T cells and its clinical significance Of: Fubai Qing, Wu Chaoyang, Xu Yaping, Wang Fa spring, Chiao-Yun Chen [Abstract] Objective: To detect the peripheral blood of esophageal cancer patients CD4 + CD25 + Foxp3 + regulatory T cells, changes were observed with clinical and pathological features of the relationship between its clinical significance. Methods: Flow cytometry 30 cases of esophageal cancer patients and 16 healthy volunteers, peripheral blood mononuclear cells in CD4 + CD25 + Foxp3 + T cells in the ratio of CD4 + T cells collected in patients with esophageal cancer clinical and pathological data, analytical research and clinical Treg cells in and the relationship between pathological features. Results: Flow cytometry showed that PBMC of patients with esophageal cancer CD4 + CD25 + Foxp3 + T cells in CD4 + T cell ratio (3.72 + -1.39)%, higher than the control group (1.15 + -0.36)%, P lt;0.01, fresh cancer control Treg cell ratio in peripheral blood of patients with age, sex, tumor location was no significant correlation (Pgt; 0.05, but not with lymph node metastasis and TNM sub- of a significant correlation (P lt;0.05). Conclusion: CD4 + CD25 + Foxp3 + regulatory T cells in immune tolerance in esophageal cancer may play an important role in the detection of esophageal cancer to determine the proportion of the disease and the prognosis value of . [Keywords:] regulatory T cells, esophageal cancer, flow cytometry [Abstract] Objective: To find out the change of CD4 + CD25 + Foxp3 + regulatory T cells in peripheral blood of esophageal cancer patients, the relationship between clinical data and pcorholozical characteristics, and to study their clinical significance.Methods: Flow cytometry was used to analyze the proportion of CD4 + CD25 + Foxp3 + T cells/CD4 + T cells in peripheral blood mononuclear cells (PBMCs) from 30 patients with esophageal cancer and 16 healt