Eye of the immune regulation mechanism.docVIP

 PAGE \* MERGEFORMAT 20 Eye of the immune regulation mechanism All the body organs or tissues have immune protection against pathogens, eye is no exception. However, the eye’s immune expression in many ways different from other organs and tissues, their uniqueness depends on the maintenance of an extremely complicated regulatory factors. As to clarify its regulatory mechanism for understanding the pathogenesis of related diseases, as well as the development of new control strategies have important clinical significance, we now have studies on this issue has become a focus of scientific research in the field one of the hot. An immune-control study of history [1,2] 19th century 70s, Doorremal found that certain human tumor cells can survive in the rabbit anterior chamber. The 20th century, 40 years, Medawar was found planted in the anterior chamber of the graft can survive a long time. He terms this phenomenon is known as ‘immune privilege (immune privilege)’, its meaning to the parts of the transplanted graft rejection may not follow the basic rules. He speculated that: (1) vaccination in these parts of the exogenous graft and the immune system have taken place in isolation; (2) Since the state is immune to ignore and therefore can not stimulate an effective anti-graft immunity. In the early 70s of this century, Kaplan and other once again observed the skin and thyroid tissue in the front room of inbred rats with the fate of allografts confirmed that they can survive in the eye for a long time. More importantly, found that: (1) transplant recipient’s immune system by producing antibodies to identify these transplantation antigens and react with them; (2) However, transplant recipients for the transplantation antigen of the cellular immune response is weakened. These findings negate the early Medawar will be immune to ignore as a basis for immune privilege hypothesis. Planted in privileged site of the graft can trigger systemic antibody response, suggesting t