Eyelid basal cell carcinoma and Statistical Analysis of Survivin Expression.docVIP

 PAGE \* MERGEFORMAT 11 Eyelid basal cell carcinoma and Statistical Analysis of Survivin Expression [Abstract] Objective: To investigate the eyelid basal cell carcinoma and the expression of Survivin. METHODS: Wuhan Central Hospital, and Department of Pathology, Zhongnan Hospital of Wuhan University from 2002 to 2009, surgical excision and biopsy of eyelid basal cell carcinoma (basalcell carcinoma, BCC) specimens A total of 20 cases, an alternative cancer, 5 cases of normal tissue as control. the eyelid basal cell carcinoma and the normal group did immunohistochemistry, the cells were observed in the expression of Survivin. HPIAS 2000 using high resolution color graphic report on management of pathology system of Survivin expression in each group for quantitative analysis. Results: eyelid basal cell carcinoma Survivin was highly expressed in cancer tissues was low Survivin expression. Image analysis showed that eyelid basal cell carcinoma tissue organization and between the Survivin The average optical density and the difference in the rate of positive area was significantly (P lt;0.01). Conclusion: Survivin in eyelid basal cell carcinoma of the abnormal expression of basal cell carcinoma on the eyelids play an important role in the development. [Keywords: eyelids; basal cell carcinoma; Survivin; statistical analysis Eyelid basal cell carcinoma (basalcell carcinoma, BCC) is the most common eyelid malignancy, accounting for malignant epithelial tumors of the eyelid for 85% to 95% [1]. Studies have shown abnormal expression of multiple oncogenes in the genesis and development of eyelid BCC important role in the process of research in cancer associated antigen genes BCC occurrence, development and the role of transfer mechanisms, for revealing the biological behavior of BCC and explore effective control methods are important. 1 Materials and methods 1.1 Materials 1.1.1 The source of specimen collection Wuhan Central Hospital, and Department of Pa