Ganoderma lucidum spores on NF-B in rat brain epilepsy immune response and behavioral effects observed.docVIP

 PAGE \* MERGEFORMAT 12 Ganoderma lucidum spores on NF-B in rat brain epilepsy immune response and behavioral effects observed [Abstract] Objective To observe and investigate the fungus spores on pentylenetetrazol (PTZ induced seizure in rat brain nuclear factor-B (NF-B and the immune reactivity to behavioral observation. Methods sub-convulsant dose of PTZ copy large rat model of chronic epilepsy, medication orally Ganoderma lucidum group and record seizures and duration of the incubation period, detected by immunohistochemistry the protein expression of brain NF-B/P65. Results rat hippocampus and cortex of each high power field ( 400 under the NF-B/65 significantly higher protein expression in model group (P lt;0.01, 17,21,25 days of modeling in the drug group than in model group had prolonged seizure latency (P lt;0.05 or P lt;0.01, hippocampus and cortex NF-B/P65 protein drug group was lower than the model group (P lt;0.01 or P lt;0.05. Conclusion NF-B may be involved in the occurrence of PTZ induced seizure development process, significantly inhibited spore NF-B protein expression, suppression of the immune inflammatory response and reduce the excitability of the nervous system, has a protective effect on nerve cells. [Keywords:] epilepsy, rats, models, animal, fungus spores, nuclear factor B Effects of ganoderma lucidum spores powder on the behaviors and immune reactivity of brain NF-B in models of epilepsy in rats ZHAO Shuang, ZHANG Sheng-chang, WANG Shu-qiu (Department of Pathophysiology, Youjiang Medical College for Nationalities, Baise, Guangxi 533000, China; Department of Anatomy, Youjiang Medical College for Nationalities, Baise, Guangxi 533000, China; Department of Pathophysiology, Basic Medical College of Jiamusi University, Jiamusi, Heilongjiang 154007 , China) Abstract: Objective To investigate the effects of ganoderm lucidum spores powder on the behaviors and immune reactivity of brain nuclear factor-B (NF-B) in rats with epil