Gastrointestinal stromal tumors and treatment of pathological analysis of.docVIP

 PAGE \* MERGEFORMAT 4 Gastrointestinal stromal tumors and treatment of pathological analysis of [Abstract] Objective: To investigate the gastrointestinal stromal tumor clinicopathologic features, immunohistochemical characteristics, biological behavior and diagnosis and treatment. Methods: Immunohistochemical S  P detected 29 cases of gastrointestinal stromal tumor CD117, CD34, SMA, Desmin, NSE, S  100 and other protein expression and clinical pathological analysis. Results: 29 cases of gastrointestinal stromal tumor CD117 expression in 26 cases accounted for 89.7%, CD34 positive expression in 21 cases, accounting for 72.4%. Follow-up of 18 patients, there are eight cases of recurrence or death, including NSE, and (or) S  100 protein expression in 6 cases. In patients with potentially malignant and malignant CD117, CD34, SMA, NSE, S  100 such proteins are significantly different in patients with benign, but there was no difference between the expression of Desmin. Conclusion: The gastrointestinal stromal tumor CD117 and CD34 is more specific marker. NSE, S  100 protein expression in the time required to attach great importance to determine the vicious, radical resection should be performed. [Keywords:] gastrointestinal stromal tumors; clinical pathology; immunohistochemistry; Treatment Gastrointestinal stromal tumor (gastrointestinal stromal tumor, GIST) is an immune phenotype expressed CD117 (c  kit protein), genetics, the existence of high frequency of c  kit gene mutation, has a special histology, immunophenotype type and molecular genetic characteristics, and in its judgments on the biological behavior of a certain level of difficulty and uncertainty of prognosis [1]. In this study the clinicopathologic features of GIST, and immunophenotypic characteristics, biological behavior and treatment of aspects. 1 Materials and methods 1.1 Clinical data Collection of hospital after surgical resection and pathological diagnosis of gastrointestina