Glutathione S-transferase P1 genotypes on the susceptibility of ulcerative colitis.docVIP

 PAGE \* MERGEFORMAT 11 Glutathione S-transferase P1 genotypes on the susceptibility of ulcerative colitis [Abstract] Objective: To investigate the glutathione S-transferase (GST) P1 genotypes on ulcerative colitis (UC) susceptibility. Methods: Using polymerase chain reaction (PCR) detected 56 cases of ulcerative colitis (UC) and 120 healthy people of the GSTP1 genotype, using x2 test, analysis and comparison of GSTP1 genotype frequencies in the UC group and between the healthy control group The distribution of differences. Results: GSTP1 variant genotypes (VaL / VaL) frequency in the UC group increased compared with healthy control group, the difference was significant (P = 0.045); Based on the clinical characteristics of UC groups stratified analysis found that VaL / VaL genotype distribution in the distal UC in the wide range of frequencies higher than the UC (P = 0.022). Conclusion: GSTP1 genotype and the susceptibility of UC. [Keywords:] glutathione S-transferase genotype susceptibility to ulcerative colitis Abstract: Objective: To investigate the effect of glutathione S-transferase P1 genotype on the susceptibility to ulcerative colitis (UC) in Chinese. Methods: Polymerase chain reaction (PCR) was used in the study of GSTP1 genotype, than the discrepancies of GSTP1 genotype frequences between 56 UC patients and 120 healthy controls were anatysed by x2 test. Results: The frequency of VaL / VaL genotype was higher in the UC patients than that in the controls (P = 0.045). And the frequency of VaL / VaL genotype was also significantly higher in distal colon patients than that in total colon patients (P = 0.022). Conclusion: The GSTP1 genotype is strongly correlated with the susceptibility to ulcerative colitis in Chinese. Keywords:: glutathione S-transferase P1; genotype; ulcerative colitis; susceptibility Glutathione S-transferase (glutathione S-transferases, GSTs) in the human body relative to metabolic processes catalyzed Ⅰ produced by a variety of