Guipi Tang rat model of depression in serum estradiol corticosterone and hippocampal morphology.docVIP

 PAGE \* MERGEFORMAT 17 Guipi Tang rat model of depression in serum estradiol corticosterone and hippocampal morphology 【Abstract】 Objective: To observe the spleen and Tang model of depression serum corticosterone, estradiol (E2) levels and hippocampal morphology, initially to explore its possible mechanisms of prevention and treatment of depression. Methods: 40 Wistar female rats were divided into blank group, model group and control group, the Chinese Medicines Board. Application of the unpredictability of moderate-intensity stimulation of chronic depression animal model to copy. Open  field behavior in rats detected by scores of corticosterone was measured by radioimmunoassay, and E2 levels, HE staining and scanning electron microscopic observation of morphological changes of the hippocampus. Results: Comparing with the blank model group and control group rats body weight, behavioral score, serum corticosterone, E2, FSH, LH levels were significantly different, hippocampus damage significantly, while the Medicines were no significant differences in the above-mentioned indicators . Conclusion: The antidepressant mechanism of the spleen and soup with the maintenance of a normal corticosterone, E2 secretion and on hippocampal morphology. 【Key Words】 Depression; spleen Soup / pharmacodynamics; estradiol (E2); corticosterone; Hippocampus; Rat Depression is a common affective disorder, female multiple. Hippocampal injury is now considered an important link in the incidence of depression. Many studies have found that hippocampal damage caused by cortisol is the main factor, estrogen is to protect the hippocampus, so for the female patients, the maintenance of normal cortisol and estrogen secretion of great significance. Clinical practice shows that the spleen soup obvious effect of the treatment of depression [1  2], but its mechanism is unclear. In this study, mainly from the study of endocrine aspects of the spleen and Tang on hippocampal