Hepatitis B and its clinical significance and impact of factors.docVIP

 PAGE \* MERGEFORMAT 6 Hepatitis B and its clinical significance and impact of factors [Keywords:] the clinical significance of hepatitis B virus detection 1 Overview Hepatitis B is viral hepatitis have been identified in the most serious hazards to human health as a hepatitis, such as first discovered in 1965, Bhumberg hepatitis B virus (HBV) surface antigen (HBsAg), HBV belongs to hepatotropic DNA Viruses Branch, the complete HBV virus, known as the Dane particle diameter of 42nm, spherical, enveloped (ie, HBsAg). Except for patients with Dane particles, there are 16 ~ 25nm spherical and rod-like body, the virus assembly excess HBsAg, HBV genome of circular double-stranded DNA from some of the composition, about 3.2Kb, there are four open reading framework, namely, S (including the pre-S1 and pre-S2), C (including the former C), P, and X4 District HBV antigens, including: 1.1 surface antigen (HBsAg) from the S gene encoding the capsid protein is HBV, including the S pre-S1 and pre-S2 protein, HBsAg is the main hallmark of HBV infection, with antigenicity, can stimulate the body to produce specific anti-HBs. Anti-HBs can neutralize HBV, is a kind of protective antibodies. 1.2 core antigen (HBcAg) is the virus nucleocapsid components encoded by the C gene for the particle state of antigen, were HBsAg-coated, and therefore can not be easily detected in infected blood. HBcAg may stimulate the body to produce anti-HBc antibodies. 1.3 e antigen (HBeAg) is also encoded by the C gene is a soluble HBV core antigen, HBeAg-positive that the virus replication in the body, infectious stronger, HBeAg can stimulate the body to produce anti-HBe antibody, this antibody has a protective effect against HBV infection. Two transmission Acute and chronic hepatitis B patients and blood of asymptomatic HBsAg-positive HBV carriers is the main source of infection, HBV primarily through blood, sexual contact, daily contact and vertical transmission. Reposted elsewhere in the pa