Hepatitis B cirrhosis progress in genetic susceptibility to.docVIP

 PAGE \* MERGEFORMAT 9 Hepatitis B cirrhosis progress in genetic susceptibility to Keywords: genetic susceptibility to chronic hepatitis B cirrhosis Review Keywords: hepatitis B, chronic; liver cirrhosis; genetic predisposition to disease; review Cirrhosis of the liver is a common chronic liver disease, hepatitis B virus (hepatitis B virus, HBV) is one of the main caused by cirrhosis of the liver. Worldwide there are about 350 million HBV carriers, HBV carriers in China account for about 1 / 3, about 20% to 30% develop into cirrhosis of the liver [1], and 2% to 5% of cirrhotic patients will develop into the liver [2], which is the life of the people constitutes a serious threat. Therefore, to clarify hepatitis B virus (HBV for short) the pathogenesis of liver cirrhosis, liver cirrhosis and liver cancer to control the occurrence and development of great significance. As human genome research continues to develop, in order to further clarify the pathogenesis of liver cirrhosis, virology and immunology in the past based on the research, some researchers have started with the genetic susceptibility to cirrhosis in hepatitis B research. As the current research is still in its infancy, genetic polymorphism detection methods and screening of candidate genes and many other questions need to be further explored. Therefore, the author reviewed the literature in recent years on the genetic susceptibility to liver cirrhosis research status reviewed, and the prospects for the study to be prospects. A cause of post-hepatitis cirrhosis There are many reasons caused by cirrhosis of the liver, viral infections, chronic alcoholism, chemical poisons, or drugs can cause cirrhosis, including hepatitis virus infection, either viral or host genetic polymorphism can be linked to post-hepatitis cirrhosis pathogenesis. 1.1 virus genotype B, hepatitis C and hepatitis D may develop into cirrhosis of the liver, mainly due to the persisten