HPLC method for the determination on the fingers orange compound berberine hydrochloride capsules.docVIP

 PAGE \* MERGEFORMAT 9 HPLC method for the determination on the fingers orange compound berberine hydrochloride capsules On: Sun Hong, Hu Shuyi, ZHANG Jianbo, Deng Lijuan [Abstract] Objective To determine the fingers orange compound berberine hydrochloride capsules, for its quality control to provide a stable and reliable method. Method using high performance liquid chromatography, Diamonsil ODS (250 mm × 4.6 mm, 5 μm) The mobile phase of acetonitrile -0.033 mol / L potassium dihydrogen phosphate (30:70), flow rate 1.0 mL / min, detection wavelength 347 nm, column temperature was 30 ℃. Results berberine 2.52 ~ 12.6 μg / mL range and the peak area showed a good linear relationship, this preparation of berberine in the average concentration of 1.686 mg / tablets. Conclusion The method is simple, accurate, and can control content of the preparation. [Keywords: compound fingers orange capsules, HPLC, berberine, Determination Keywords:: compound Wuzhigan capsules, HPLC, berberine chloride, content determination Fingers orange capsule compound is contained in the ministerial standard varieties of closing fingers orange compound developed from the film based on the prescription by the fingers orange, the credit component of wood and other herbs, with the heat of the table, dampness antidiarrheal effect, for the treatment of acute gastroenteritis, Fengreganmao, dysentery and other diseases, a better clinical effect. for the effective control of product quality, we used high performance liquid chromatography (HPLC), on the merits of wood at Fangzhong Jun main component of drug berberine hydrochloride were determined The method is simple, sensitive, reproducible and specific. An instrument and reagent LC-10ATVP high performance liquid chromatography (Shimadzu), ultrasonic cleaner (KQ-100DB, Kunshan Ultrasonic Instrument Co., Ltd.), Sartorius electronic balance (Germany). Compound fingers orange capsules (Franc Limin Pharmaceutical Group , lot numbe