Hypothalamic mTOR signaling pathway regulating effect of the energy balance.docVIP

 PAGE \* MERGEFORMAT 9 Hypothalamic mTOR signaling pathway regulating effect of the energy balance [Keywords:] hypothalamus; mTOR; energy balance Developed countries, obesity has seriously affected the quality of people’s lives, and with the improvement of living standards in China, obesity is gradually apparent, is a healthy one of the main killers. Obesity causes other diseases such as diabetes, the incidence of cardiovascular and cerebrovascular diseases such as also increasing, so obesity has become a world problem. pathogenesis of obesity has not been fully clarified, the general view that the formation process of obesity, genetic factors (obesity susceptibility genes) and environmental factors (such as diet, exercise, social factors and certain drugs ) played an important role. but generally agreed that diet is an important reason, so obesity is also known as rich man’s disease. When the energy intake of food over the body to provide energy consumption occurs when the body energy is balanced, excess calories will be fat form of storage, accumulation of fat leads to obesity. Therefore, the understanding of food intake and body weight regulation in understanding the molecular mechanism of obesity is important, and a series of studies showed that the hypothalamus in the regulation of body energy balance plays a key The role of [1]. hypothalamus through mammalian target of rapamycin protein (mammalian target of rapamycin, mTOR) signaling pathway to changes in perception of energy feedback on the food intake, so as to effectively regulate body energy balance [2]. 1 mTOR pathway is involved in energy metabolism TOR is highly conserved in animals serine threonine protein kinase, since it is a first discovered immunosuppressant rapamycin target proteins, hence the name. But then found that, TOR function far beyond the role of the immune system involved in yeast, Drosophila, mammals and feel the energy changes as affected by cell division [3], the mech