Hydrogen sulfide on the multiple organ dysfunction syndrome in rats.docVIP

 PAGE \* MERGEFORMAT 16 Hydrogen sulfide on the multiple organ dysfunction syndrome in rats Of: Liu Hao, Xi Xiao Zhong, Cheng Yonggang, Li Jie, Yong-Xiao Cao [Abstract] Objective To study the hydrogen sulfide (H2S) on the multiple organ dysfunction syndrome (MODS) organ protective effect in rats. Methods 40 SD rats were randomly divided into: normal control group; MODS modeling 12h group; MODS modeling 24h group; sodium hydrosulfide (NaHS) protect the 12h group; NaHS protect the 24h group. kit assay of serum superoxide dismutase (SOD), malondialdehyde (MDA), glutathione glutathione peroxidase (GSH Px), serum alanine aminotransferase (ALT), creatine kinase (CK) and creatinine (Cr) content were observed in rat heart, liver, lung, kidney, small intestine histopathological changes. Results H2S protection of serum SOD, GSH Px was significantly higher (P lt;0.05), MDA, ALT, CK and Cr were significantly lower (P lt;0.05, P lt;0.01); H2S protection group big rat heart, liver, lung, kidney, small intestine comprehensive organ damage score in model group was significantly improved (P lt;0.05). Conclusion H2S has a significant anti-inflammatory and organ protective effect on organ damage in rats has a protective effect MODS. [Keywords:] hydrogen sulfide; sodium hydrosulfide; multiple organ dysfunction syndrome; rat ABSTRACT: Objective To investigate the possible protective effects of hydrogen sulfide (H2S) on rats with multiple organ dysfunction syndrome (MODS). Methods NaHS was taken as a donor of H2S. Forty Sprague Dawley rats were divided into 5 groups with 8 rats in each group: sham group, MODS 12h model group, MODS 24h model group, NaHS protection 12h and 24h groups. The content of superoxidase dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH Px), alanime transaminse (ALT), creatine kinase (CK) and creatinine (Cr) in serum were measured, respectively. The histopathological changes in the heart, liver, lung, kidney and small intesti